6-[1-(2-fluoropyridin-3-yl)-5-methyltriazol-4-yl]quinoline
FPTQ
CAS: 864863-72-9
Molecular Formula: C17H12FN5
6-[1-(2-fluoropyridin-3-yl)-5-methyltriazol-4-yl]quinoline - Names and Identifiers
| Name | FPTQ |
| Synonyms | FPTQ 6-[1-(2-fluoropyridin-3-yl)-5-methyltriazol-4-yl]quinoline Quinoline, 6-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]- |
| CAS | 864863-72-9 |
6-[1-(2-fluoropyridin-3-yl)-5-methyltriazol-4-yl]quinoline - Physico-chemical Properties
| Molecular Formula | C17H12FN5 |
| Molar Mass | 305.31 |
| Solubility | 10 mM in DMSO |
| Storage Condition | -20℃ |
| In vivo study | FPTQ (5-20 μM) decreases the number of neutrophils migrating to the amputation site in zebrafish larvae by tail amputation. In the tailfin wound method, the number of neutrophils collecting at the wound site also decreases in a dose-dependent manner in zebrafish.In a LPS-induced inflammation zebrafish model, LPS solution is injected into the yolks of Tg(mpx:EGFP) i114 zebrafish larvae and exposed the zebrafish larvae immediately to FPTQ treatment.FPTQ (20 μM; 4 hours) significantly decreases the fluorescent neutrophils after yolk injection and has an anti-inflammatory effect during the early phase of inflammation. |
6-[1-(2-fluoropyridin-3-yl)-5-methyltriazol-4-yl]quinoline - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.275 ml | 16.377 ml | 32.754 ml |
| 5 mM | 0.655 ml | 3.275 ml | 6.551 ml |
| 10 mM | 0.328 ml | 1.638 ml | 3.275 ml |
| 5 mM | 0.066 ml | 0.328 ml | 0.655 ml |
Last Update：2024-01-02 23:10:35
6-[1-(2-fluoropyridin-3-yl)-5-methyltriazol-4-yl]quinoline - Reference Information
| biological activity | FPTQ is a potent mGluR1 antagonist, inhibition of human and mouse IC50 values were 6 nM and 1.4 nM, respectively. FPTQ has antioxidant and anti-inflammatory effects. |
| Cell Line: | RAW264.7 macrophage cells |
| Concentration: | 1, 10, or 20 μM |
| Incubation Time: | 24 hours |
| Result: | Decreased IL-1β and IL-6 mRNA expression |
Last Update：2024-04-09 21:21:28
![6-[1-(2-fluoropyridin-3-yl)-5-methyltriazol-4-yl]quinoline](http://res.chembk.com/assets/str/2d/8/86/864863-72-9.png)
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CAS: 864863-72-9
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